Resting heart rate (variability) and cognition relationships reveal cognitively healthy individuals with pathological amyloid/tau ratio

Introduction Resting heart rate (HR) and variability (HRV) have been linked with cognition in the general population older individuals. The knowledge of this aspect heart-brain relationship is relatively absent individuals early Alzheimer's disease (AD) pathology. This study explores relationships HR, HRV, cognitively healthy pathological amyloid/tau ratio (CH-PATs) cerebral spinal fluid (CSF) compared to those normal (CH-NATs). Methods We examined between 1) resting HR Mini‐Mental State Examination (MMSE); 2) brain processing during Stroop interference; 3) vagally mediated HRV (vmHRV) task switching performance. Results Our studies showed that CH-NATs, CH-PATs higher presented lower MMSE, less activation interference processing. In addition, vmHRV was significantly correlated accuracy but not CH-PATs. Discussion These three different tests indicate dysfunctional connections CH-PATs, suggesting a potential cardio-cerebral integration.